Abstract: This talk is concerned with motions for untangling polygonal linkages (open and closed chains) in 2 and 3 dimensions. Unknotted linkages that cannot be untangled are called locked. Recent results for different constraints on the input configurations and motions allowed, are discussed. In addition, the history of some special cases of the problem proposed by Cauchy in 1813 and Erdos in 1935, are reviewed. These results enjoy a wide spectrum of applications ranging from knot theory to bioinformatics, where knots and molecules, respectively, are modelled as closed 3-dimensional polygons.